Triple pathology.
نویسندگان
چکیده
منابع مشابه
Staging of Alzheimer's Pathology in Triple Transgenic Mice: A Light and Electron Microscopic Analysis
The age-related pathological cascade underlying intraneuronal tau formation in 3xTg-AD mice, which harbor the human APP(Swe), PS1(M126V) , and Tau(P301L) gene mutations, remains unclear. At 3 weeks of age, AT180, Alz50, MC1, AT8, and PHF-1 intraneuronal immunoreactivity appeared in the amygdala and hippocampus and at later ages in the cortex of 3xTg-AD mice. AT8 and PHF-1 staining was fixation ...
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The coexistence of three intracranial lesions related to epileptic pathogenesis is known as 'triple pathology' and has rarely been reported. In this study we report a case of temporal lobe epilepsy (TLE) with the coexistence of hippocampal sclerosis (HS), focal cortical dysplasia (FCD) and ganglioglioma in the temporal lobe. A 29-year-old male who had experienced recurrent seizures for four yea...
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Reducing excessive accumulation of amyloid-β (Aβ) in Alzheimer's disease (AD) is a key objective of most AD therapies, and inhibition of angiotensin-converting enzyme (ACE) may delay onset or progression of AD. The effects of an ACE-inhibitor (ACE-I) and an angiotensin II receptor blocker (ARB) on Aβ and tau pathology in a triple transgenic (3xTGAD) mouse model of AD were investigated. 9-10mont...
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We have previously reported that chronic ibuprofen treatment improves cognition and decreases intracellular Aß and phosphorylated-tau levels in 3xTg-AD mice. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that independently of its anti-inflammatory effects has anti-amyloidogenic activity as a gamma-secretase modulator (GSM) and both activities have the potential to decrease Aß path...
متن کاملDetecting progression of Alzheimer’s disease pathology in the triple transgenic mouse brain using 1H MRS
J. Kim, S-P. Lee, M. L. Michaelis, and I-Y. Choi Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS, United States, Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS, United States, Department of Pharmacology and Toxocology, University of Kansas, Lawrence, KS, United States, Department of Neurology, Molecular &...
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ژورنال
عنوان ژورنال: Postgraduate Medical Journal
سال: 1994
ISSN: 0032-5473
DOI: 10.1136/pgmj.70.827.646